Pancreatic disease patients are at higher risk for Clostridium difficile infection compared to those with other co-morbidities

AbstractBackgroundSurveillance ofClostridium difficile infection (CDI) in patients with underlying diseases is important because use of prophylactic antibiotics makes them prone to CDI. Epidemiology of CDI in this high-risk population is poorly understood. A study was conducted to evaluate the impact of CDI in patients with specific underlying co-morbidities.MethodA total of 2036 patients, whose fecal samples were processed forC. difficile toxin A and B assay by ELISA formed the basis of study. Patients with underlying diseases were classified based on the organ/kind of disease as pancreatic (n  =  340), renal (n  =  408), hepatic (n  =  245), malignant (n  =  517) and miscellaneous disease (n  =  526). Laboratory records of clinical and demographic details were reviewed. The association of CDI with age, gender, antibiotic receipt, clinical symptoms and underlying co-morbidities was analyzed. Variation in CDI cases based on age groups was also investigated.ResultClostridium difficile toxin positivity was 21.6% in general, whereas it was 30.6% in the pancreatic, 17.9% in the renal, 19.6%, in the hepatic, 21.3% in the malignancy and 20.0% in the miscellaneous disease groups. Toxin positivity was the lowest (14.8%) for female gender under renal disease and the highest (31.8%) for patients aged 40 to  
Source: Gut Pathogens - Category: Microbiology Source Type: research

Related Links:

Abstract Bats are associated with the emergence of several mammalian diseases. Their sessional migration, and tendency to form large colonies in close proximity to human habitats enables effective intra- and inter-species transmission of pathogens. Clostridioides difficile is an important enteric pathogen in humans and animals; however, the source of its dissemination in the population is unknown. The purpose of this study was to determine the prevalence of C. difficile in bats, and to characterize C. difficile isolates. Feces (n = 93) was sampled from bats during their migration across Europe. Eight...
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research
Diverting loop ileostomy (LI) is increasingly favored over total abdominal colectomy (TAC) for the surgical management of patients with fulminant Clostridium difficile colitis, according to a new study.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Gastroenterology News Source Type: news
AbstractClostridium difficile infection (CDI) is a severe and potentially deadly infectious colitis whose incidence is dramatically increasing in the last decades, with more virulent strains. CDI should be suspected in case of unexplained diarrhea and abdominal pain in patients with a recent history of antibiotic use and healthcare exposures; diagnosis is based on a combination of clinical and laboratory findings with demonstration of C. difficile toxins by stool test. The advantages of contrast-enhanced computed tomography (CECT) are the noninvasiveness and the ability to evaluate both the colonic wall and the adjacent so...
Source: La Radiologia Medica - Category: Radiology Source Type: research
Retrospective analysis of data from 43 US hospitals suggest 67.8% of patients received excess antibiotic therapy which was not associated with lower rates of any adverse outcomes, including death, readmission, emergency department visit, or Clostridium difficile infection.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
(American Society for Microbiology) Surgical gowns and stainless steel remained contaminated with the pathogen Clostridium difficile even after being treated with the recommended disinfectant. The research is published July 12 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Condition:   Clostridium Difficile Infection Intervention:   Other: Standard Practice to Prevent Hospital Onset CDI Sponsor:   NorthShore University HealthSystem Research Institute Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, IEC polarized monolayers were subjected to hazardous or non-hazardous proteins in nine exposures over 30 days and compared to a single exposure of the same protein. The objective was to evaluate whether repeated exposures to a protein differently alter barrier integrity or compromise cell viability compared to single exposures. Proteins tested included Clostridium difficile toxin A, Streptolysin O, Wheat Germ Agglutinin, Phaseolus vulgaris Hemagglutinin-E, bovine serum albumin, porcine serum albumin, and fibronectin. Evidence of diminished barrier integrity and/or cell viability following exposure to hazardo...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research
by Amy E. Rohlfing, Brian E. Eckenroth, Emily R. Forster, Yuzo Kevorkian, M. Lauren Donnelly, Hector Benito de la Puebla, Sylvie Doubli é, Aimee Shen The gastrointestinal pathogen,Clostridioides difficile, initiates infection when its metabolically dormant spore form germinates in the mammalian gut. While most spore-forming bacteria use transmembrane germinant receptors to sense nutrient germinants,C.difficile is thought to use the soluble pseudoprotease, CspC, to detect bile acid germinants. To gain insight into CspC ’s unique mechanism of action, we solved its crystal structure. Guided by this structure, we...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Since the introduction of the concept of healthcare-associated pneumonia (HCAP) in the 2005 update on the treatment of nosocomial pneumonias by the American Thoracic Society and the Infectious Diseases Society of America [1], there has been considerable controversy over whether this new category has been helpful or harmful. The core of the problem is the tension between clinicians perceiving that missing a methicillin-resistant Staphylococcus aureus (MRSA) or Pseudomonas aeruginosa may have dire consequences for their patient and the goals of antibiotic stewardship in reducing the use of too broad spectrum antibiotics driv...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
More News: Cancer & Oncology | Clostridium Difficile | Epidemiology | Laboratory Medicine | Microbiology | Pancreas | Study