Pancreatic disease patients are at higher risk for Clostridium difficile infection compared to those with other co-morbidities

AbstractBackgroundSurveillance ofClostridium difficile infection (CDI) in patients with underlying diseases is important because use of prophylactic antibiotics makes them prone to CDI. Epidemiology of CDI in this high-risk population is poorly understood. A study was conducted to evaluate the impact of CDI in patients with specific underlying co-morbidities.MethodA total of 2036 patients, whose fecal samples were processed forC. difficile toxin A and B assay by ELISA formed the basis of study. Patients with underlying diseases were classified based on the organ/kind of disease as pancreatic (n  =  340), renal (n  =  408), hepatic (n  =  245), malignant (n  =  517) and miscellaneous disease (n  =  526). Laboratory records of clinical and demographic details were reviewed. The association of CDI with age, gender, antibiotic receipt, clinical symptoms and underlying co-morbidities was analyzed. Variation in CDI cases based on age groups was also investigated.ResultClostridium difficile toxin positivity was 21.6% in general, whereas it was 30.6% in the pancreatic, 17.9% in the renal, 19.6%, in the hepatic, 21.3% in the malignancy and 20.0% in the miscellaneous disease groups. Toxin positivity was the lowest (14.8%) for female gender under renal disease and the highest (31.8%) for patients aged 40 to  
Source: Gut Pathogens - Category: Microbiology Source Type: research

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Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research
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Source: La Radiologia Medica - Category: Radiology Source Type: research
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Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
(American Society for Microbiology) Surgical gowns and stainless steel remained contaminated with the pathogen Clostridium difficile even after being treated with the recommended disinfectant. The research is published July 12 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Condition:   Clostridium Difficile Infection Intervention:   Other: Standard Practice to Prevent Hospital Onset CDI Sponsor:   NorthShore University HealthSystem Research Institute Completed
Source: - Category: Research Source Type: clinical trials
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Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
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