TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression

ConclusionsThese data show that the known chromatin remodeling and pioneer functions of AP-1 are a pervasive aspect of epigenetic control of transcription, and thus, the risk in coronary disease-associated loci, and that interaction of AP-1 with TCF21 to control epigenetic features, contributes to the genetic risk in loci where they co-localize.

Source: Genome Medicine - April 23, 2019 Category: Genetics & Stem Cells Source Type: research