Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long ‐term follow‐up of predictors, surveillance, and outcome in clinical practice

ConclusionOnly a small number of ALT tests performed during MTX therapy in RA capture an elevation. A pre ‐treatment elevation of ALT was the strongest predictor for early and recurrent ALT elevations during therapy. This study supports a more individualized approach to monitoring and handling of ALT elevations during MTX therapy in RA than recommended in current guidelines.

https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13576?af=R

Source: International Journal of Rheumatic Diseases - April 21, 2019 Category: Rheumatology Authors: Johanna Karlsson Sundbaum, Niclas Eriksson, P är Hallberg, Niklas Lehto, Mia Wadelius, Eva Baecklund Tags: ORIGINAL ARTICLE Source Type: research