School screening for cardiovascular risk

Universal screening for cardiovascular risk factors in children could improve the early diagnosis of hypertension, dyslipidemia, and diabetes. The current childhood obesity epidemic underscores the relevance of screening for these comorbidities. Siegel et al report the findings of an initial feasibility pilot study of a small group of children aged 12-14 performed in a middle-school setting. The authors showed that screening for hypertension, dyslipidemia, and diabetes was feasible in this setting.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research

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In conclusion, older adults exhibited decreased markers of UPR activation and reduced coordination with autophagy and SC-associated gene transcripts following a single bout of unaccustomed resistance exercise. In contrast, young adults demonstrated strong coordination between UPR genes and key regulatory gene transcripts associated with autophagy and SC differentiation in skeletal muscle post-exercise. Taken together, the present findings suggest a potential age-related impairment in the post-exercise transcriptional response that supports activation of the UPR and coordination with other exercise responsive pathways (i.e....
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Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Diabetes has grown to become one of the most important public health concerns of our time. A review by the Harvard T.H. Chan School of Public Health has shown that the number of affected people has quadrupled in the last three decades. Type 2 diabetes (T2D), a type of diabetes traditionally occurring in adults and associated with obesity and a sedentary lifestyle, is now the ninth leading cause of death worldwide. It therefore comes as no surprise that this rapidly emerging epidemic is giving rise to a profusion of diabetes-related complications. What are the usual diabetes-related complications? As diabetes is a systemic ...
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ConclusionsChinese adults had the higher prevalence of prediabetes and T2DM and a higher probability of T2DM at the same BMI level compared with Swedish adults. These results indicate the importance of addressing the ongoing obesity epidemic as a matter of urgency in order to curb what has become an apparent diabetes epidemic in both countries.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
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Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
In a society where physical activity is limited and food supply is abundant, metabolic diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hypertension, dyslipidemia, and carbohydrate intolerance, and significantly increases type 2 diabetes mellitus risk. Insulin resistance and hyperinsulinemia are consistent characteristics of MetS, but which of these features is the initiating insult is still widely debated. Regardless, both of these conditions trigger adverse responses from the pancreatic β cell, which is responsible for produci...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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