Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet-Induced Obese Minipigs.

CONCLUSIONS: Together, these data are consistent with the existence of an early-onset tranport deficiency for endogenous circulating leptin into the brain in individuals developing obesity, preceding the acquisition of hypothalamic leptin resistance. Although additional studies are required to identify the underlying mechanisms, our study paves the way for the development of new preclinical pharmacological models targeting the restoration of the shuttling of peripheral leptin into the central nervous system to manage obesity. PMID: 31006983 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31006983?dopt=Abstract

Source: Obesity - April 20, 2019 Category: Eating Disorders & Weight Management Authors: Chmielewski A, Hubert T, Descamps A, Mazur D, Daoudi M, Ciofi P, Fontaine C, Caiazzo R, Pattou F, Prevot V, Pigeyre M Tags: Obesity (Silver Spring) Source Type: research