Class i and class ii small leucine-rich proteoglycans in human cutaneous pacinian corpuscles.

CLASS I AND CLASS II SMALL LEUCINE-RICH PROTEOGLYCANS IN HUMAN CUTANEOUS PACINIAN CORPUSCLES. Ann Anat. 2019 Apr 18;: Authors: García-Piqueras J, García-Mesa Y, Feito J, García B, Quiros LM, Martín-Biedma B, Cobo T, Vega JA, García-Suárez O Abstract Pacinian corpuscles are onion bulb-like multilayered mechanoreceptors that consist of a complicated structure of axon terminals, Schwann related cells (inner core), endoneural related cells (intermediate layer) and perineurial related cells (outer core-capsule). The cells forming those compartments are continuous and share the properties of that covering the nerve fibers. Small leucine-rich proteoglycans are major proteoglycans of the extracellular matrix and regulate collagen fibrillogenesis, cell signalling pathways and extracellular matrix assembly. Here we used immunohistochemistry to investigate the distribution of class I (biglycan, decorin, asporin, ECM2 and ECMX) and class II (fibromodulin, lumican, prolargin, keratocan and osteoadherin) small leucine-rich proteoglycans in human cutaneous Pacinian corpuscles. The distribution of these compounds was: the inner core express decorin, biglycan, lumican, fibromodulin, osteoadherin; the intermediate layer display immunoreactivity for osteoadherin; the outer core biglycan, decorin, lumican, fibromodulin and osteoadherin; and the capsule contains biglycan, decorin, fibromodulin, and lumican. Asporin, prolargin and keratocan were und...
Source: Annals of Anatomy - Category: Anatomy Authors: Tags: Ann Anat Source Type: research
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