Severe quetiapine voluntary overdose successfully treated with a new hemoperfusion sorbent.

Severe quetiapine voluntary overdose successfully treated with a new hemoperfusion sorbent.
Int J Artif Organs. 2019 Apr 22;:391398819837686
Authors: Giuntoli L, Dalmastri V, Cilloni N, Orsi C, Stalteri L, Demelas V, Giuliani G, Gordini G, De Ponti F, La Manna G
Abstract
Quetiapine overdose, although rare, is mainly linked with tachycardia, QTc-interval prolongation, somnolence, coma, hyperglycemia, and eventually hepatotoxicity and myocarditis. Extracorporeal techniques for quetiapine removal might be helpful, but only a few cases are reported in the literature. We here describe the case of a 27-year-old healthy woman, admitted to our Intensive Care Unit after voluntary quetiapine intake and successfully treated with CytoSorb hemoperfusion in combination with continuous renal replacement therapy (CRRT), in order to accelerate quetiapine elimination. This is the first published experience about the potential application of hemoadsorption therapies, as CytoSorb sorbent, in large overdoses of quetiapine and this approach might be feasible to rapidly remove the substance from blood, stabilizing the patient condition.
PMID: 31006356 [PubMed - as supplied by publisher]

Source: The International Journal of Artificial Organs - April 21, 2019 Category: Transplant Surgery Authors: Giuntoli L, Dalmastri V, Cilloni N, Orsi C, Stalteri L, Demelas V, Giuliani G, Gordini G, De Ponti F, La Manna G Tags: Int J Artif Organs Source Type: research