Clinical Correlates of Insulin Resistance in Chronic Schizophrenia: Relationship to Negative Symptoms

This study presents findings from a large sample with extensive clinical phenotyping—allowing us to examine the relationships of insulin resistance with a number of key psychopathological, cognitive, and functioning measures, using multivariate methods to assess the relative contributions of different factors to metabolic abnormalities. PwS often have many risk factors for metabolic abnormalities: lifestyle habits, medications, and underlying biological mechanisms including inflammation and oxidative stress. Treatment and prevention of metabolic abnormalities in PwS can be particularly challenging due to these multiple risk factors (28–32). This study aims to better understand the factors most highly associated with metabolic dysfunction in this high-risk group.In the present cross-sectional study, we aimed to compare insulin resistance between adults with chronic schizophrenia and nonpsychiatric comparison (NC) subjects, with similar age, sex, and race/ethnicity distribution. Furthermore, within the PwS we examined the relationships between insulin resistance and psychopathology, cognition, and everyday functioning. We performed targeted statistical analyses using the least absolute shrinkage and selection operator (LASSO) method to see what group of factors were most associated with insulin resistance in PwS. These findings will help us better understand what patient characteristics and clinical factors would predict response to interventions to prevent or treat...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

Related Links:

Conclusions: The use of real-time ultrasound guidance was associated with a lower rate of iatrogenic pneumothoraces.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
Conclusions: The prevalence of long-term posttraumatic stress disorder symptoms among family members of acute respiratory distress syndrome survivors is high. Family members with preexisting mental health disorders, recent experiences of serious physical illness, and family members of previously healthy patients are at increased risk for posttraumatic stress disorder symptoms.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
This study utilized data from The National Longitudinal Transition Study-2 (NLTS-2), a 10-year longitudinal dataset that includes high school students with various disabilities. The study proposed a theoretical framework for sense of school community through maximized school assets and minimized school challenges. The study sample included a total of 1,180 high school students, 11th (n = 443) and 12th (n = 737) graders who completed surveys. Multiple linear regression analysis revealed that a combination of school assets and school challenges of high school experience predicted sense of school c...
Source: Journal of Prevention and Intervention in the Community - Category: International Medicine & Public Health Tags: J Prev Interv Community Source Type: research
Publication date: 13 June 2019Source: Cell, Volume 177, Issue 7Author(s): Diana CrowAn “off-the-shelf” cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. Other companies are following suit, harnessing iPSCs’ self-renewal ability to manufacture cell therapies that don’t require customization for each patient. But some experts aren’t sure such therapies are a good idea.
Source: Cell - Category: Cytology Source Type: research
MRI studies show multiple sclerosis brain changes linked to depression, but randomized controlled trials of antidepressants in this population are lacking.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news
A new scientific statement outlines guidance on managing concomitant heart failure and diabetes, common conditions that often occur together.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
Conclusions:Modeling neck circumference while allowing for differences by Mallampati class showed a nearly threefold increase in the risk of SDB with increasing neck circumference in women with Mallampati class 1. Other potential sites of airway obstruction need to be investigated in future research.Citation:Bourjeily G, Chambers A, Salameh M, Bublitz MH, Kaur A, Coppa A, Risica P, Lambert-Messerlian G. Anthropometric measures and prediction of maternal sleep-disordered breathing.J Clin Sleep Med. 2019;15(6):849–856.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Study Objectives:Studies have shown racial differences in circadian rhythm in African Americans when compared to non-Hispanic whites, and an association between circadian dyssynchrony and depression. We hypothesized that the prevalence of delayed sleep time is greater in African Americans when compared to whites and that delayed sleep time is associated with depression.Methods:We analyzed data from the Sleep Heart Health Study (SHHS), a large community-based sample. Delayed sleep time was defined as self-reported weeknight bedtime after midnight. Depression was defined based on participant's response to the question,&ldquo...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Conclusions:Maternal depressive symptoms, food insecurity, and household insecurity (factors associated with low socioeconomic status) may be associated with a negative sleep environment and poor toddler sleep quality, potentially because of decreased implementation of bedtime routines.Commentary:A commentary on this article appears in this issue on page 821.Citation:Covington LB, Rogers VE, Armstrong B, Storr CL, Black MM. Toddler bedtime routines and associations with nighttime sleep duration, and maternal and household factors.J Clin Sleep Med. 2019;15(6):865–871.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Study Objectives:Controversy exists as to whether elevated loop gain is a cause or consequence of obstructive sleep apnea (OSA). Upper airway surgery is commonly performed in Asian patients with OSA who have failed positive airway pressure therapy and who are thought to have anatomical predisposition to OSA. We hypothesized that high loop gain would decrease following surgical treatment of OSA due to reduced sleep apnea severity.Methods:Polysomnography was performed preoperatively and postoperatively to assess OSA severity in 30 Chinese participants who underwent upper airway surgery. Loop gain was calculated using a valid...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
More News: Academia | Actos | Alcoholism | Biology | Bipolar | Brain | Caffeine | Cardiology | Cardiovascular | Child Abuse | Child Development | China Health | Cholesterol | Clinical Trials | Dementia | Depression | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Diets | Disability | Eating Disorders & Weight Management | Education | Endocrinology | Epidemiology | Genetics | Grants | Heart | Hormones | Insulin | International Medicine & Public Health | Italy Health | Laboratory Medicine | Mania | Men | Metabolic Syndrome | Neurology | Nicotine | Nursing | Nutrition | Obesity | Orthopaedics | Pathology | PET Scan | Psychiatry | Psychology | Reproduction Medicine | Schizophrenia | Smokers | Sports Medicine | Statistics | Study | Substance Abuse | Substance Abuse Disorders | Tics | Topamax | Universities & Medical Training | USA Health | Wales Health | Weight Loss | WHO | Zyprexa