Clinical Correlates of Insulin Resistance in Chronic Schizophrenia: Relationship to Negative Symptoms

This study presents findings from a large sample with extensive clinical phenotyping—allowing us to examine the relationships of insulin resistance with a number of key psychopathological, cognitive, and functioning measures, using multivariate methods to assess the relative contributions of different factors to metabolic abnormalities. PwS often have many risk factors for metabolic abnormalities: lifestyle habits, medications, and underlying biological mechanisms including inflammation and oxidative stress. Treatment and prevention of metabolic abnormalities in PwS can be particularly challenging due to these multiple risk factors (28–32). This study aims to better understand the factors most highly associated with metabolic dysfunction in this high-risk group.In the present cross-sectional study, we aimed to compare insulin resistance between adults with chronic schizophrenia and nonpsychiatric comparison (NC) subjects, with similar age, sex, and race/ethnicity distribution. Furthermore, within the PwS we examined the relationships between insulin resistance and psychopathology, cognition, and everyday functioning. We performed targeted statistical analyses using the least absolute shrinkage and selection operator (LASSO) method to see what group of factors were most associated with insulin resistance in PwS. These findings will help us better understand what patient characteristics and clinical factors would predict response to interventions to prevent or treat...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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CONCLUSIONS The network pharmacology analysis reveals the molecular biological mechanism of Artemisia annua anti-NSCLC via multiple active components, multi-channels, and multi-targets. This suggests that Artemisia annua might be developed as a promising anti-NSCLC drug. PMID: 32474568 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Optical scanning holography (OSH) is an attractive technique since 3D information can be obtained with a single pixel detector. However, ...
Source: Optics Letters - Category: Physics Authors: Source Type: research
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2), the cause of coronavirus disease 2019 (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS–CoV-2, nor therapy for those who develop COVID-19. Immune (i.e., “convalescent”) plasma refers to plasma that is collected from individuals following resolution of infection and development of antibodies. Passive antibody administration through transfusion of convalescent plasma may offer the only short-term strategy for conferring immediate immunity to susceptib...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Dr Fauci says he hasn ’t spoken to Trump in two weeks; New Zealand to consider easing restrictions earlier than planned; Mexico deaths pass 10,000. Follow the latest updatesSingapore reopens schoolsUK: Critics round on No 10 over ‘ridiculous’ rules for 14-day quarantineAustralia coronavirus updates – liveCoronavirus latest: at a glanceSee all our coronavirus coverage6.46amBSTTheAssociated Pressis carrying a report that says Chinese officials sat on releasing the genetic map, or genome, of the coronavirus for over a week after multiple government labs had fully decoded it, not sharing details key to ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Infectious diseases Science Microbiology Medical research UK news US news Australia news Source Type: news
Publication date: Available online 31 May 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Badmus O. Olufunto, Njan Anoka, Ologe M. Olufunmilayo, Olatunji A. Lawrence
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
BACKGROUND: The United States (US) and Canada are in the midst of an opioid overdose epidemic. Many people who use illicit drugs (PWUD) do not call an emergency number 911 at the scene of an overdose due to fear of arrest. In the US and Canada, when an ind...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Providers involved in the care of children, adolescents, and adults with mental health issues are rightly focused on stabilizing those individuals. However, they should not forget the families and communities; they, too, are grieving with the toll of t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
We compared the efficacy and safety of transcranial direct current stimulation (tDCS) vs. Sertraline in the treatment of Major Depressive Disorder (MDD) in South Korean participants. This was a multi-center, double blind, active controlled study with non-i...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Program and Other Evaluations, Effectiveness Studies Source Type: news
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