Epilepsy-on-a-Chip System for Antiepileptic Drug Discovery

Conclusion: We screened 12 receptor tyrosine kinases inhibitors, and EGFR/ErbB-2 and cFMS inhibitors were identified as novel antiepileptic compounds. Significance: This epilepsy-on-a-chip system provides the means for rapid dissection of complex signaling pathways in epileptogenesis, paving the way for high-throughput antiepileptic drug discovery.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research