For teens living with cancer, keeping life as ‘normal’ as possible

With a new center dedicated to teenage patients, Yale New Haven Children ’s Hospital is working to make the battle against cancer an easier one for young adults.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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Authors: Gang W, Tanjun W, Yong H, Jiajun Q, Yi Z, Hao H Abstract Osteosarcoma (OS) is the most common primary bone tumor that affects adolescents and young adults. Disruption of microRNA (miRNA) regulation is well established in the pathophysiology of different cancers, including OS. Increased expression of miR-9 in OS positively correlates with the tumor size, clinical stage, and distant metastasis. In the present study, we used two different OS cell lines, MG-63 and Saos-2, as in vitro models. Small interfering RNA against miR-9 and miR-9 mimics were used to study the function of miR-9 in these two cell lines. W...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Osteosarcoma (OS) is the most common primary bone malignancy and is a leading cause of cancer-related death in children and young adults. Combination chemotherapy developed 3 decades ago significantly improved long-term survival compared to surgery alone. However, despite notable tumor cytoreduction and remission, the 5-year survival rate has remained static at ∼70% since, and the surviving patients have high chemoresistance with sustained risk of recurrent OS that has propensity to metastasize. After metastasis, the 5-year survival rate is abysmally low (∼10% to 20%). Emerging new evidence has revealed that within...
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Symposium Source Type: research
Tobacco use in the U.S. is changing, according to new data from the U.S. Centers for Disease Control and Prevention (CDC). The number of American adults who smoke fell to a new low in 2018, while e-cigarette use continued to climb. About a fifth of American adults used some type of tobacco product in 2018, according to the data. Cigarettes were the most popular, used by 13.7% of adults. That’s a small decrease from 14% the year before, and another record low for the U.S., which has seen a two-thirds decline in smoking since 1965. Meanwhile, e-cigarette use rose from 2.8% of U.S. adults in 2017 to 3.2% in 2018. Use of...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized embargoed study public health Source Type: news
Thousands of cases missed by testing failures Related items fromOnMedica Long delay after FIT linked to higher risk of cancer FOB associated with rise in all-cause mortality Invest in workforce to roll out bowel cancer screening, urges former health secretary NHS must improve access to screening to save lives Young adults ’ rate of bowel cancer is rising in Europe
Source: OnMedica Latest News - Category: UK Health Source Type: news
WEDNESDAY, Nov. 13, 2019 -- Melanoma incidence seems to be decreasing in adolescents and young adults, according to a study published online Nov. 13 in JAMA Dermatology. Kelly G. Paulson, M.D., Ph.D., from the Fred Hutchinson Cancer Research Center...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(University of Washington Health Sciences/UW Medicine) Cases of melanoma among US adolescents and young adults declined markedly from 2006 to 2015 - even as the skin cancer's incidence continued to increase among older adults and the general population during the span, new research shows. The finding, based on national cancer-registry data, suggests that public-health efforts advocating sun protection are changing behaviors among millennials and post-millennials, surmised the investigators from the University of Washington School of Medicine and Fred Hutchinson Cancer Research Center.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
British Journal of Cancer, Published online: 13 November 2019; doi:10.1038/s41416-019-0632-1Survival after cancer in children, adolescents and young adults in the Nordic countries from 1980 to 2013
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Meshinchi S Abstract PURPOSE: A cryptic inv(16)(p13.3q24.3) encoding the CBFA2T3-GLIS2 fusion is associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our understanding of the pathogenesis of this fusion through transcriptome profiling. EXPERIMENTAL DESIGN: Available RNA from children and young adults with de novo AML (N=1,049) underwent transcriptome sequencing (mRNA and miRNA). Transcriptome profiles for those with the CBFA2T3-GLIS2 fusion (N=24) and without (N=1,025) were contrasted to define fusion-specific miRNAs, genes, and pathways. Clinical annotations defined...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
AbstractPresence of minimal residual disease (MRD) following induction chemotherapy is a well-recognized risk factor to predict relapse in acute lymphoblastic leukemia (ALL). There is paucity of data on MRD and outcome in ALL from India. We share our experience in establishing a flow cytometry-based MRD assay for ALL with emphasis on determination of the number of patients who had MRD on day 35 of induction therapy and its correlation with outcome and other prognostic factors. We prospectively studied MRD in patients with ALL less than 25  years who achieved morphological complete remission with induction therapy. The...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
Did you know that a viral infection can lead to a number of different types of cancer? If that comes as a surprise to you, you’re not alone. In fact, according to a new study, many people have no idea that a common viral infection called human papilloma virus (HPV) can cause cancer of the genitals, anus, mouth, and throat, as well as cervical cancer. Viral infections and cancer The connection between certain viral infections and cancer has been recognized for many years. Some of the most well-established examples include hepatitis C, human immunodeficiency virus (HIV), and human papillomavirus (HPV). One thing these ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Cancer Infectious diseases Men's Health Sexual Conditions Vaccines Women's Health Source Type: blogs
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