Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity.

Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity.
Trends Genet. 2019 Apr 17;:
Authors: Sabarís G, Laiker I, Preger-Ben Noon E, Frankel N
Abstract
The current paradigm in the field of gene regulation postulates that regulatory information for generating gene expression is organized into modules (enhancers), each containing the information for driving gene expression in a single spatiotemporal context. This modular organization is thought to facilitate the evolution of gene expression by minimizing pleiotropic effects. Here we review recent studies that provide evidence of quite the opposite: (i) enhancers can function in multiple developmental contexts, implying that enhancers can be pleiotropic, (ii) transcription factor binding sites within pleiotropic enhancers are reused in different contexts, and (iii) pleiotropy impacts the structure and evolution of enhancers. Altogether, this evidence suggests that enhancer pleiotropy is pervasive in animal genomes, challenging the commonly held view of modularity.
PMID: 31005339 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - April 16, 2019 Category: Genetics & Stem Cells Authors: Sabarís G, Laiker I, Preger-Ben Noon E, Frankel N Tags: Trends Genet Source Type: research