CRP/prealbumin, a novel inflammatory index for predicting recurrence after radical resection in gastric cancer patients: post hoc analysis of a randomized phase III trial

AbstractBackgroundSerum prealbumin (PALB) can predict the prognosis of patients with gastric cancer (GC). However, the prognostic value of combination of C-reactive protein and PALB (CRP/PALB) remains unclear.MethodsA total of 419 gastric cancer patients included in a clinical trial (NCT02327481) were analyzed. The present study is a substudy of the trial. Receiver operating characteristic (ROC) curves were generated, and by calculating the areas under the curve (AUC) and the C-index, the discriminative ability of each inflammatory index was compared, including CRP/PALB, C-reactive protein/albumin, Glasgow prognostic score (GPS), modified GPS, systemic immune-inflammation index, neutrophil –lymphocyte ratio, and platelet–lymphocyte ratio.ResultsUltimately, 401 patients were included in this study. The optimal cutoff value of CRP/PALB was 17.7. According to this cutoff point, the entire sample was divided into a CRP/PALB  
Source: Gastric Cancer - Category: Gastroenterology Source Type: research

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Conclusion: Our results showed that PVT1 can inhibit the apoptosis and enhance the 5-Fu resistance of gastric cancer through the activation of Bcl2. PVT1 has the potential to serve as an indicator to predict 5-Fu treatment resistance. PMID: 31205469 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Conclusions: Primary carcinoma with plasmacytoid morphology is a dedifferentiated variant of adenocarcinoma or poorly cohesive carcinomas. Vimentin positive dedifferentiated-poorly cohesive carcinomas should be considered as mesenchymal-type highly malignant carcinomas. This rare histologic variant of gastrointestinal cancer might respond to anti-c-MET tyrosine kinases. PMID: 31205468 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
In conclusion, our results suggest that patients with −181 GG and AG genotypes have an increased risk for gastric cancer and this polymorphism may be a candidate marker for predicting individuals who are at higher risk to gastric cancer. Further work with a larger sample size including other criteria such as H. pylori infection status is needed for more accuracy.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
ConclusionsOur results are not supportive of Tisseel tissue sealing property on the intrathoracic oesophago-gastric anastomosis and fibrin sealant’s use cannot be justified.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
This report examines why patients with a curative treatment plan for oesophago-gastric cancer do not go on to receive surgery. The National Oesophago-Gastric Cancer Audit plans to follow-up this initial investigation with further evaluation to enable specific recommendations in subsequent works.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conclusions: Diagnostic tests ofH.  pylori infection mostly followed Japanese Society forHelicobacter Research guidance, although some antibody measurements were timed inappropriately. Vonoprazan appears to increase the success rate of primary therapy.Digestion
Source: Digestion - Category: Gastroenterology Source Type: research
Publication date: Available online 18 June 2019Source: Preventive MedicineAuthor(s): Benjamin D. Hallowell, Meheret Endeshaw, Matthew T. McKenna, Virginia Senkomago, Hilda Razzaghi, Mona SaraiyaAbstractFrom 1970 to 2010 the foreign-born population in the United States has rapidly increased from 9.6 to 40.0 million individuals. Historically, differences in cancer rates have been observed between US-born and foreign-born individuals. However, comprehensive and up-to-date data on US cancer rates by birth place is lacking. To compare cancer mortality rates among foreign and US-born individuals, population-based cancer mortalit...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Conclusion: Our results show that gastric cancer and adjacent tissues have an expression profile for miRNAs analyzed very similar, indicating that miRNAs studied are intimately associated with field cancerization in gastric cancer. The overexpression of TS-miRs in adjacent tissue is likely an antitumor mechanism. Additionally, these miRNAs have great accuracy in discriminating non-cancer from other tissues and can be potentially useful as biomarkers for gastric cancer.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Ma Zhang Li To inform public health policy and research, we analyzed the patterns of life lost to cancers and evaluated the cancer burden in China. Based on the published Chinese Cancer Registry Annual Report and related literature in 2013, we calculated the cancer-related mortality and potential years of life lost (PYLL) by age, sex, districts (urban or rural), to describe the patterns of life lost to cancers. The high death-risk cancers in China were lung, liver, stomach, esophageal, colorectal, breast, pancreatic, brain and nervous system, and ovarian cancers, and leukemia. Liver and esophageal cancers were...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Condition:   Metastatic Gastric Adenocarcinoma Interventions:   Drug: S1;   Drug: Paclitaxel;   Drug: Bevacizumab;   Drug: Oxaliplatin Sponsor:   China Medical University, China Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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