Synergistic triad epistasis of epigenetic H3K27me modifier genes, EZH2, KDM6A , and KDM6B , in gastric cancer susceptibility

ConclusionsAll three H3K27me modifier genes are individually associated with gastric cancer susceptibility with synergistic triad interaction. Not only two enzymes with the same function (KDM6A and KDM6B), but also those with opposite functions (EZH2 versus KDM6A or KDM6B) synergistically affect H3K27me consequences such as gastric cancer susceptibility.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research