Cancers, Vol. 11, Pages 569: The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma
Cancers, Vol. 11, Pages 569: The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma
Cancers doi: 10.3390/cancers11040569
Authors:
Sascha Marx
Yong Xiao
Marcel Baschin
Maximilian Splittstöhser
Robert Altmann
Eileen Moritz
Gabriele Jedlitschky
Sandra Bien-Möller
Henry W.S. Schroeder
Bernhard H. Rauch
The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the last decade. Malignant gliomas differ tremendously from malignancies outside the central nervous system because they virtually never form distant metastases. This review summarizes the current understanding of the platelet–immune cell communication and its potential role in glioma resistance and progression. Particularly, we focus on platelet-derived proinflammatory modulators, such as sphingosine-1-phosphate (S1P). The multifaceted interaction with immune cells puts the platelet into an interesting perspective regarding the recent advances in immunotherapeutic approaches in malignant glioma.
Source: Cancers - Category: Cancer & Oncology Authors: Sascha Marx Yong Xiao Marcel Baschin Maximilian Splittst öhser Robert Altmann Eileen Moritz Gabriele Jedlitschky Sandra Bien-M öller Henry W.S. Schroeder Bernhard H. Rauch Tags: Review Source Type: research