Severe pneumonia and acute respiratory distress syndrome: Implication of unconventional T cells.

[Severe pneumonia and acute respiratory distress syndrome: Implication of unconventional T cells]. Rev Mal Respir. 2019 Apr 17;: Authors: Jouan Y, Si-Tahar M, Paget C Abstract Pneumonia is frequently complicated by occurrence of acute respiratory distress syndrome (ARDS), consequently to dysregulated inflammatory response. However, mechanisms driving this dysregulation are poorly understood. To address this, "unconventional T-cells (UTC)" -γδT, NKT and MAIT cells- appear to be relevant targets due to their key role in orchestrating anti-microbial immune response in the lung. Thus, using an experimental and translational approach, we test the hypothesis that a tight regulation of UTC is mandatory to fine-tune host response, and, subsequently to prevent emergence of an aberrant response leading to excessive tissue damages, and eventually, ARDS. PMID: 31005423 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

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Source: Influenza and Other Respiratory Viruses - Category: Virology Authors: Tags: Original Article Source Type: research
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