Molecules, Vol. 24, Pages 1584: Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade
Molecules, Vol. 24, Pages 1584: Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade
Molecules doi: 10.3390/molecules24081584
Authors:
Min Hee Yang
Jong Hyun Lee
Jeong-Hyeon Ko
Sang Hoon Jung
Gautam Sethi
Kwang Seok Ahn
The epithelial–mesenchymal transition (EMT) is a phenomenon that facilitates epithelial cells to acquire invasive potential to induce the initiation the metastatic spread of tumor cells. Here, we determined if brassinin (BSN) can affect the EMT process and deciphered its anti-cancer effects. BSN attenuated the levels of EMT linked genes and suppressed transforming growth factor beta (TGF-β)-mediated regulation of diverse mesenchymal markers. Additionally, BSN did increase the expression of various epithelial marker proteins in lung cancer cells. TGF-β-induced morphological changes and induction of invasive ability of tumor cells was also found to be abrogated by BSN treatment. Finally, BSN not only suppressed constitutive, but also inducible phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) phosphorylation in tumor cells.
Source: Molecules - Category: Chemistry Authors: Min Hee Yang Jong Hyun Lee Jeong-Hyeon Ko Sang Hoon Jung Gautam Sethi Kwang Seok Ahn Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Chemistry | Epithelial Cancer | Genetics | Lung Cancer