GSE80571 Genome-wide target analysis of Class III HD-ZIP transcription factors [RNA-Seq]

Contributors : Jared A Sewell ; Jeff A LongSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaGene regulation in both plants and animals is orchestrated by complex interactions between multiple, often times related, factors. How these related factors interact and compete to alter gene expression is a key question that is not fully understood. In Arabidopsis, the Class III Homedomain-Leucine Zipper (HD-ZIPIII) family of transcription factors regulates key developmental processes such as shoot stem cell formation and display complex genetic interactions. We show that HD-ZIPIIIs form heterodimers in planta, co-occupy hundreds of genomic locations and regulate target gene expression both positively and negatively. Transcriptional repression by HD-ZIP IIIs is correlated to co-occupancy and association with the co-repressor TOPLESS.  We find the HD-ZIPIIIs act on entire pathways at multiple, sometimes opposing steps and this regulation can occur at a stage, tissue or cell type specific level.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Arabidopsis thaliana Source Type: research