Tetrandrine induces apoptosis in human neuroblastoma through regulating the Hippo/YAP signaling pathway.

In this study, we confirmed that TET inhibits proliferation and induces apoptosis in neuroblastoma (NB) in vitro and in vivo. Moreover, we revealed that the anti-cancer ability of TET is associated with a decreased expression of anti-apoptotic Bcl-2. Importantly, we demonstrated that the Hippo/YAP pathway is involved in down-regulating of Bcl-2. Notably, YAP overexpression promoted proliferation and suppressed apoptosis, even partially reversed TET-induced effects in NB cells. Our findings support the prospect that TET could be a potential therapeutic agent for NB, and suggest that targeting the Hippo/YAP pathway may represent a valuable approach to NB treatment.
PMID: 31003773 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - April 15, 2019 Category: Biochemistry Authors: Zhao Q, Jia X, Zhang Y, Dong Y, Lei Y, Tan X, Williamson RA, Wang A, Zhang D, Ma J Tags: Biochem Biophys Res Commun Source Type: research