Inhibition of GIP signaling extends lifespan without caloric restriction.

CONCLUSIONS: Although maintenance of CR is difficult, food intake and muscle endurance of Gipr-/- mice were similar to those of wild-type mice. Inhibition of GIP signaling may be a novel strategy to extend the lifespan of diabetic patients.
PMID: 31003779 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - April 16, 2019 Category: Biochemistry Authors: Hoizumi M, Sato T, Shimizu T, Kato S, Tsukiyama K, Narita T, Fujita H, Morii T, Sassa MH, Seino Y, Yamada Y Tags: Biochem Biophys Res Commun Source Type: research