Cancers, Vol. 11, Pages 567: Immunophenotype of T Cells Expressing Programmed Death-1 and Cytotoxic T Cell Antigen-4 in Early Lung Cancer: Local vs. Systemic Immune Response

We report for the first time the differential expression of checkpoint molecules on CD4+ and CD8+ lymphocytes at a different stage of activation in the local environment of lung cancer. Moreover, the circulating T cells have a distinct expression of these receptors, which suggests their poor utility as biomarkers for immunotherapy.

Source: Cancers - April 20, 2019 Category: Cancer & Oncology Authors: Iwona Kwiecien Tomasz Skirecki Ma łgorzata Polubiec-Kownacka Agata Raniszewska Joanna Domagala-Kulawik Tags: Article Source Type: research