Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles

We examined contributions of inflammatory molecules lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), stress-activated kinases (c-Jun N-terminal kinase [JNK] and p38), arginase, and reactive oxygen species to coronary arteriolar dysfunction in a porcine model of type 1 diabetes. Coronary arterioles were isolated from streptozocin-induced diabetic pigs and control pigs for vasoreactivity and molecular/biochemical studies.

Source: Journal of Molecular and Cellular Cardiology - April 19, 2019 Category: Cytology Authors: Travis W. Hein, Xin Xu, Yi Ren, Wenjuan Xu, Shu-Huai Tsai, Naris Thengchaisri, Lih Kuo Source Type: research