Solubility measurement, Hansen solubility parameters and solution thermodynamics of gemfibrozil in different pharmaceutically used solvents.

Solubility measurement, Hansen solubility parameters and solution thermodynamics of gemfibrozil in different pharmaceutically used solvents. Drug Dev Ind Pharm. 2019 Apr 17;:1-27 Authors: Kalam MA, Alshehri S, Alshamsan A, Alkholief M, Ali R, Shakeel F Abstract Gemfibrozil (GEM) is cholesterol-lowering agent which is being proposed as poorly water soluble drug (PWSD). Temperature based solubility values of GEM are not yet available in literature or any pharmacopoeia/monograph. Hence, the present studies were carried out to determine the solubility of PWSD GEM (as mole fraction) in various pharmaceutically used solvents such as "water (H2O), methanol (MeOH), ethanol (EtOH), isopropanol (IPA), 1-butanol (1-BuOH), 2-butanol (2-BuOH), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO) and Transcutol® (THP)" at the temperatures ranging from "T = 298.2 K to 318.2 K" under atmospheric pressure "p = 0.1 MPa". Equilibrium/experimental solubilities of GEM were recorded by applying a saturation shake flask methodology and regressed using "van't Hoff and Apelblat models". Hansen solubility parameters for GEM and various pharmaceutically used solvents were estimated using HSPiP software. The solid states of GEM (both in pure and equilibrated states) were studied by "Differential Scanning Calorimetry" which confirmed no transformation of GEM after equilibrium. Ex...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research