Tumour microenvironment responsive nanoconstructs for cancer theranostic

Publication date: Available online 19 April 2019Source: Nano TodayAuthor(s): Arif Gulzar, Jiating Xu, Chen Wang, Fei He, Dan Yang, Shili Gai, Piaoping Yang, Jun Lin, Dayong Jin, Bengang XingAbstractThe tumour mass is made up of not only of a heterogeneous population of cancer cells nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors besides extracellular matrix proteins, together recognized as the tumour microenvironment (TME). Tumour development is overwhelmingly affected through the dealings of cancer cells with their environment which eventually conclude whether the primary tumour is eliminated, metastasizes or creates dormant micro metastases. The TME may perhaps shape therapeutic responses as well as resistance. Some inimitable features of TME, for example vascular abnormalities, hypoxia, acidic pH and glutathione (GSH) are comparative to normal tissue. Several types of cells, together with tumour cells, macrophages, immune and fibroblast cells are nourished by flawed blood vessels in the solid tumour. To dispense anticancer agents to tumour sites nanovehicles can be competent carts. For augmented therapeutic efficacy, TME is the key for designing of nanoparticles (NPs). In this review, we will discuss the TME and summarize the current advancement in several nano-formulations for cancer therapy, with an extraordinary stress on TME-responsive ones. Scheme 1 highlights several TME modulation tactics with positive cancer therapeut...
Source: Nano Today - Category: Nanotechnology Source Type: research

Related Links:

Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC01506J, CommunicationYuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, Chuan Zhang Polygemcitabine nanogels assembled from DNA-like polygemcitabine undergo rapid intracellular degradation to generate active gemcitabine derivatives for enhanced cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: 2019Source: Materials Today: Proceedings, Volume 13, Part 2Author(s): Nareg Ohannesian, Carlos Trevino De Leo, Karen S. MartirosyanAbstractDextran coated biocompatible water-based magnetite (Fe3O4) nanostructured media was produced via microfluidic process at various flow rates. The influences of dextran molecular weight on the magnetite particle size and magnetic property of nano fluid were investigated. Magnetite produced at flow rate of 0.04 mL/s showed uniform particle size distribution with average size 10 nm and saturation magnetization (Ms) up to 60 emu/g. The X-ray diffraction pattern indicates pu...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: 2019Source: Materials Today: Proceedings, Volume 13, Part 2Author(s): Javier Donoso-Quezada, Daniel Guajardo-Flores, José González-ValdézAbstractExosomes are membrane-derived nanovesicles secreted by a variety of cell types to the extracellular space for intercellular communication. Based on this biological function, exosomes have been used in numerous applications such as drug delivery. In this work, exosomes isolated from MCF7, Caco2, PC3 and HepG2 cell lines were characterized and loaded with bioactive compounds from black bean extract by electroporation. The cellular uptake and th...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Here, one of the leading researchers working on the biochemistry of senescent cells - and their relevance to aging - considers the state of development of senolytic therapies. These are treatments, largely small molecule drugs at this stage, but also including suicide gene therapies, immunotherapies, and more, that are capable of selectively destroying some fraction of the senescent cells present in old tissues. There is tremendous enthusiasm in the scientific and development communities for the potential to create significant degrees of rejuvenation via this approach. The results in mice are far and away more impressive a...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Publication date: 21 May 2019Source: Cell Reports, Volume 27, Issue 8Author(s): Ivan Perrot, Henri-Alexandre Michaud, Marc Giraudon-Paoli, Séverine Augier, Aurélie Docquier, Laurent Gros, Rachel Courtois, Cécile Déjou, Diana Jecko, Ondine Becquart, Hélène Rispaud-Blanc, Laurent Gauthier, Benjamin Rossi, Stéphanie Chanteux, Nicolas Gourdin, Beatrice Amigues, Alain Roussel, Armand Bensussan, Jean-François Eliaou, Jérémy BastidSummaryImmune checkpoint inhibitors have revolutionized cancer treatment. However, many cancers are resistant to ICIs, and the targe...
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Lodovichi S, Mercatanti A, Cervelli T, Galli A Abstract Knowledge of interaction network between different proteins can be a useful tool in cancer therapy. To develop new therapeutic treatments, understanding how these proteins contribute to dysregulated cellular pathways is an important task. PARP1 inhibitors are drugs used in cancer therapy, in particular where DNA repair is defective. It is crucial to find new candidate interactors of PARP1 as new therapeutic targets in order to increase efficacy of PARP1 inhibitors and expand their clinical utility. By a yeast-based genome wide screening, we previously...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 20 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Pavel Vodicka, Sona Vodenkova, Alena Opattova, Ludmila VodickovaAbstractThe last decade witnessed an increase in the use of comet assay for DNA damage monitoring in cancer patients and controls. Apart from case-control studies, reports described the determination of DNA damage prior to (baseline value) and after chemo-/radiotherapy, the treatment resulted in significantly elevated DNA damage. However, studies on DNA damage as a factor reflecting cancer prognosis and therapy prediction are scarc...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
This study aimed to investigate the treatment effects of combining TAE therapy with LY2109761, a transforming growth factor-beta (TGF-β) receptor I kinase inhibitor, on suppressing tumour growth and metastasis. We simulated the changing tumour microenvironment before and after TAE using both in vitro and in vivo models. In vitro, we evaluated the altered migration and invasion properties of HepG2 cells using migration and invasion assays. In addition, western blot analysis was used to investigate molecular mechanisms underlying the biological activities of LY2109761 in HepG2 cells. In vivo, we combined LY2109761 with ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Ovarian cancer is a common type of gynecologic tumor and the most lethal gynecologic malignancy worldwide; the mortality rate of ovarian cancer has not decreased significantly in the past decades. Most patients are diagnosed at the late stages because of atypical symptoms and lacking the effective early diagnostic measures. The reasons for oncogenesis and development in ovarian cancer are not clear. Macrophages are immune cells derived from the innate immune system. Macrophages have two states of polarization (M1 and M2) that develop in response to different stimuli. The polarization and differentiation of macrophages into...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Xu Cheng, Dapeng Li, Min Sun, Le He, Yan Zheng, Xin Wang, Rupei TangAbstractChemotherapeutic drugs have a series of limitations in the conventional clinical treatments, mainly including serious adverse effects and multidrug resistance (MDR). Herein, we developed a pH-sensitive polymeric nanoparticle with using poly(ortho ester urethanes) copolymers for co-delivering doxorubicin (DOX) and pyrrolidinedithiocarbamate (PDTC) to settle these problems. Dual-drug-loaded nanoparticles were nano-sized (˜220 nm) with t...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
More News: Cancer | Cancer & Oncology | Cancer Therapy | Environmental Health | Nanotechnology