DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network.

DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network. Chem Commun (Camb). 2019 Apr 18;: Authors: Lin Y, Jiang L, Huang Y, Yang Y, He Y, Lu C, Yang H Abstract DNA-triggered reversible isolation and recovery of circulating tumor cells (CTCs) is presented based on a multivalent dual-specific aptamer-tethered rolling circle amplification (MA-RCA) network. The multivalent binding sites endow the MA-RCA network with a strong binding ability towards CTCs, and the repeated cell capture/release processes are also actualized in a noninvasive manner. PMID: 30997454 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research
More News: Chemistry