Wash-in/wash-out phase xenon-enhanced area-detector CT (ADCT): utility for regional ventilation, pulmonary functional loss and clinical stage evaluations of smokers.

Wash-in/wash-out phase xenon-enhanced area-detector CT (ADCT): utility for regional ventilation, pulmonary functional loss and clinical stage evaluations of smokers. Acta Radiol. 2019 Apr 18;:284185119840647 Authors: Ohno Y, Fujisawa Y, Sugihara N, Kishida Y, Koyama H, Seki S, Yoshikawa T Abstract BACKGROUND: Xenon (Xe)-enhanced area-detector computed tomography (ADCT) can visualize regional distribution of Xe within the lungs and demonstrate regional ventilation differences in smokers and patients with pulmonary diseases. PURPOSE: The purpose of this study was to evaluate the capability of wash-in and wash-out (WI/WO) phase Xe-enhanced ADCT for detecting regional ventilation differences based on underlying lung conditions, pulmonary functional loss evaluation, and clinical stage prediction for smokers with and without chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: The pulmonary function test as well as inspiratory/expiratory unenhanced and WI/WO phase Xe-enhanced ADCT were prospectively administered to a group of 40 smokers consisting of 25 men (mean age ± standard deviation [SD] = 65.1 ± 9.5 years) and 15 women (65.2 ± 9.4 years), after which WI, WO, WI/WO ratio, and ventilation ratio as well as parametric response maps were generated. All Xe-enhanced ADCT indexes and pulmonary function test results were subjected to step-wise regression analyses...
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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Introduction: Thoracic computed tomography (CT) is a clinically established diagnostic technique to detect structural pulmonary abnormalities but provides no functional pulmonary information.Objectives: The current study aims to demonstrate the use of the CT-based full-scale airway network (FAN) flow model to assess ventilation in COPD patients and to compare the modelling results obtained with hyperpolarized Xenon-129 (HPX) magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) imaging data.Methods: Pulmonary ventilation in nine COPD patients was modelled using the CT-based FAN flow model....
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Imaging Source Type: research
Conclusion: BODE index, CT PA/AO ratio, post-6MWT oxygen saturation, and serum ghrelin level are useful noninvasive predictors for PH in patients with COPD.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
We examined the components of expiratory gas using exhalation components analysis equipments (Brethmass). The subjects also underwent COPD Assessment Test (CAT), pulmonary function tests, and Multi-detecter computed tomography (MDCT). We analyzed the relation between the components in gas analysis and the clinical parameters.Results: There were significant negative correlations between the parameters of airflow limitation and the chemical components with mass number 51 and 59(r=-0.3, p=0.01). The parameters of emphysematous changes significantly correlated with the chemical elements with mass number 59 (r=0.44, p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Introduction: Eosinophils have a key role in the pathogenesis of COPD as a marker of therapeutic response to inhaled corticosteroids. Some studies indicate that eosinophils may have an immunoregulatory role related to the presence of emphysema. The aim of this study was to investigate the relationship between the presence of pulmonary emphysema and the blood eosinophil count (and percentage) in a COPD population.Methods: patients from the COPD cohort of the Hospital de la Princesa (Madrid, Spain) were studied. Information about blood test, chest CT-scan and pulmonary function was analysed. The correlation between pulmonary...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
ConclusionThis study revealed the current status of lung diseases potentially related to tobacco smoking in Fukuoka Prefecture. Both COPD and CPFE were highly related to tobacco smoking, whereas 30% of patients with IIPs had never smoked.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Smoke-measuring smart shirts, breath sound analyzing algorithms, and smart inhalers pave the way of pulmonology and respiratory care into the future. As the number of patients suffering from asthma, COPD, or lung cancer due to rising air pollution and steady smoker-levels will unfortunately not decrease any time soon, we looked around what technology can do to help both patients and caregivers. The results are breathtaking. Attacks of breathlessness are too common The diseases which pulmonologists and respiratory care specialists attempt to fight are among the most common conditions in the modern world – and t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Future of Medicine Health Sensors & Trackers AI asthma cancer cancer treatment care COPD diagnostics inhaler lung lung cancer management medical specialty pulmonology respiratory respiratory care Source Type: blogs
Abstract Special attention has emerged towards biomass smoke-induced chronic obstructive pulmonary disease (COPD), providing new knowledge for prevention and therapeutic approach of non-smoker COPD patients. However, the understanding of biomass smoke COPD is still limited and somewhat controversial. The aim of the present study was to compare COPD exclusively caused by tobacco smoking with COPD exclusively caused by environmental or occupational exposures. For this cross-sectional study, COPD patients were recruited from outpatient clinics and formed two groups: non-smoker COPD group (n=16) with exposure to bioma...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
This study investigated whether DISH is associated with restrictive spirometry pattern (RSP) in former and current smokers. METHODS: 1,784 participants with complete post-bronchodilator spirometry who did not meet spirometric criteria for COPD at time of enrollment in the COPDGene study were included in this study. Subjects were classified as RSP if they had Forced Expiratory volume in one second \(FEV1) to Forced Vital Capacity (FVC) ratio> 0.7 with an FVC
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
Conclusion: Serum concentration and alleleic conformation of SFTPD has a significantly high predictive value for COPD and AECOPD. Thus, these can be tested further and could be applied as a predictive or prognostic marker. Introduction Chronic Obstructive Pulmonary Disease (COPD) affects lungs and exhibits irreversible airflow conditions that leads to improper respiratory function (Carolan et al., 2014). COPD is a global disease burden which accounts for ~3 million deaths annually (Zemans et al., 2017) and is responsible for the increase in worldwide mortality and morbidity (Dickens et al., 2011). Chronic Obstructi...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study aimed to explore association between the CSA of small pulmonary vessel and arterial stiffness in healthy male smokers.MethodsWe enrolled 90 male non ‐smokers and 90 male smokers (age: 51.5 ± 9.7 years and 52.1 ± 7.9 years, respectively). All subjects underwent chest computed tomography (CT), pulmonary function test and baPWV measurement. We evaluated the total CSAs less than 5 mm2 using ImageJ software and divided by the total lung area (%CSA
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
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