An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses

Changes in the methodologies used to deliver radiotherapy may soon be approaching, challenging many of the classical approaches that have been a cornerstone of current clinical practice. At the center of this paradigm shift are the long-standing radiation therapy treatment approaches for multiple cancer types that utilize low doses and low dose rates in a variety of fractionation schedules, all designed to exploit potential differences between normal tissue and tumor radiosensitivity. The underlying premise is that dose fractionation preferentially favors the recovery of normal tissue over tumors from the harmful effects of radiation, thereby avoiding unacceptable, or even lethal normal tissue complications during the course of tumor sterilization.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research