A Pilot Metabolomics Study of Tuberculosis Immune Reconstitution Inflammatory Syndrome

The human immunodeficiency virus (HIV) causes functional disruption of the immune response and impairs host ability to control infection by Mycobacterium tuberculosis (Walker et al., 2013) - the etiological agent of tuberculosis (TB). In 2014, there were 9.6 million cases of TB, of which 1.2 million (12.5%) were co-infected with HIV (WHO, 2016). The World Health Organization recommends that all persons with HIV and active TB be promptly treated with antiretroviral therapy (ART) in order to reduce morbidity and mortality (WHO, 2017).

Source: International Journal of Infectious Diseases - April 18, 2019 Category: Infectious Diseases Authors: Carlos A.M. Silva, Barbara Graham Andre, Kristofor Webb, Laura Vari Ashton, Marisa Harton, Annie Luetkemeyer, Samantha Bokatzian, Reem Almubarak, Sebabrata Mahapatra, Laura Hovind, Michelle A. Kendall, Diane Havlir, John T. Belisle, Mary Ann De Groote Source Type: research