De-escalation from ticagrelor to clopidogrel in acute coronary syndrome patients: a systematic review and meta-analysis

In conclusion, de-escalation commonly occurs in real-world practice. Although rates of major cardiovascular and bleeding events in this analysis were generally low, the profile of patients suitable for de-escalation, the impact of de -escalation on adverse clinical outcomes and how this is affected by the timing after index ACS warrants further large-scale investigation.
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research