AbstractReproducibility is a highly desired feature of scientific investigation in general, and it has special connotations for research in pharmacokinetics, a vibrant field with over 500,000 publications to-date. It is important to be able to differentiate between genuine heterogeneity in pharmacokinetic parameters from heterogeneity that is due to errors and biases. This overview discusses efforts and opportunities to diminish the latter type of undesirable heterogeneity. Several reporting and research guidance documents and standards have been proposed for pharmacokinetic studies, but their adoption is still rather limited. Quality problems in the methods used and model evaluations have been examined in some empirical studies of the literature. Standardization of statistical and laboratory tools and procedures can be improved in the field. Only a small fraction of pharmacokinetic studies become pre-registered and only 9995 such studies have been registered in ClinicalTrials.gov as of August 2018. It is likely that most pharmacokinetic studies remain unpublished. Publication bias affecting the results and inferences has been documented in case studies, but its exact extent is unknown for the field at-large. The use of meta-analyses in the field is still limited. Availability of raw data, detailed protocols, software and codes is hopefully improving with multiple ongoing initiatives. Several research practices can contribute to greater transparency and reproducibility for ph...
CORRIGENDUM FOR "Reductions in Insulin Resistance are Mediated Primarily via Weight Loss in Subjects With Type 2 Diabetes on Semaglutide". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832679 [PubMed - in process]
ERRATUM FOR "Genetic Link Between Gender Dysphoria and Sex Hormone Signaling". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832678 [PubMed - in process]
CORRIGENDUM FOR "Role of Activin-A and Myostatin and Their Signaling Pathway in Human Myometrial and Leiomyoma Cell Function". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832677 [PubMed - in process]
CORRIGENDUM for "Dietary Calcium Intake and Bone Loss Over 6 Years in Osteopenic Postmenopausal Women". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832676 [PubMed - in process]
ERRATUM FOR "Serum Lipids in Association With Type 2 Diabetes Risk and Prevalence in a Chinese Population". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832675 [PubMed - in process]
CORRIGENDUM FOR "The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832674 [PubMed - in process]
ERRATUM FOR "Insights Into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832673 [PubMed - in process]
CORRIGENDUM FOR "Lipid Profiling of Peri-implantation Endometrium in Patients With Premature Progesterone Rise in the Late Follicular Phase". J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832672 [PubMed - in process]
Abstract Hepatitis B surface antigen (HBsAg) level plays an important role in conjunction with other markers such as hepatitis B envelope antigen (HBeAg) and hepatitis B virus (HBV) deoxyribonucleic acid levels to predict disease activity in chronic Hepatitis B (CHB). Quantification of HBsAg is useful in differentiating carriers from active hepatitis in HBeAg negative patients, and current guidelines recommend monitoring of pegylated interferon alpha treatment in CHB infection. However, there are only few studies about the role of quantitative HBsAg (qHBsAg) monitoring in HIV-HBV coinfected patients. Studies have ...
Abstract In recent years, there have been numerous calls by researchers to adopt multi-disciplinary and international perspectives to address the HIV pandemic. Meaningful and prudent public health policy should be based on sound empirical data and research. Henceforth, our study aims to contribute to the current literature by conducting a comprehensive global mapping and determine the landscapes of HIV/AIDS research covering the years between 1983 and 2017. Bibliometric and content analysis was used to describe trends in research productivity, usages, research collaborations, and clusters of research topics. Explo...