TRIF and MAVS signaling pathways regulate RAB27A induction and melanosome transfer by TLR3 signaling in human epidermal melanocytes

Human epidermis is a barrier defending human internal organs from outer environment such as microbes, ultraviolet, dryness, etc. Epidermal melanocytes localize in basal layer of the epidermis and express Toll-like receptors (TLR) to sense innate immune stimuli [1,2]. We previously reported that TLR2 and TLR3 are involved in melanocyte functions such as melanogenesis, intra/extra cellular melanosome transfer, and melanosome transfer to keratinocytes [3]. TLR3 agonist Poly(I:C) increases RAB27  A mRNA and protein expression and enhances co-localization of RAB27 A and Gp100+melanosome at cell periphery in human melanocyte.

Source: Journal of Dermatological Science - April 18, 2019 Category: Dermatology Authors: Saaya Koike, Kenshi Yamasaki, Takeshi Yamauchi, Ryoko Shimada-Omori, Kenichiro Tsuchiyama, Setsuya Aiba Tags: Letter to the Editor Source Type: research