002 RNA-seq analysis reveals unique transcriptome signatures in dermatomyositis with distinct autoantibodies specificities

To investigate the transcriptional difference between dermatomyositis with distinct autoantibodies. we performed high throughput sequencing technologies in 27 dermatomyositis and 7 healthy volunteers. These dermatomyositis patients were segregated into three subsets based on distinct autoantibodies present in their sera. Including 10 patients that anti-melanoma differentiation associated gene 5 antibody (MDA-5) positive with interstitial lung disease (ILD, and 8 patients that anti-transcriptional intermediary factor 1- γ(TIF1-γ) antibody positive with tumor, and 9 patients that both two antibodies are negative with neither interstitial lung disease nor tumor.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research