008 Assessment of eosinophils degranulation in skin in drug reaction with eosinophilia and systemic symptoms (DRESS)

BACKGROUND: DRESS for "Drug Reaction with Eosinophilia and Systemic Symptoms" is a drug-induced hypersensivity syndrom that can lead to severe organs failure. The role of eosinophils (Eo) in tissue damage remains unknown. We aimed to analyze the activation status of cutaneous Eo in DRESS. METHOD: Paraffin-embedded skin biopsies of patients from a French University hospital were retrospectively collected. We included 40 patients (2 groups of drug reaction): 19 MPE (maculopapular exanthema) and 21 DRESS.

https://www.jidonline.org/article/S0022-202X(19)30275-1/fulltext?rss=yes

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: F. Dezoteux, J. Gibier, B. Lopez, A. Bongiovanni, G. Lef èvre, D. Staumont-Sallé Tags: Adaptive and Auto-Immunity Source Type: research