010 IL-27 in macrophages mediates T cell survival and dermal cluster formation in allergic contact hypersensitivity

Re-exposure to a relevant skin allergen initiates the efferent phase and clinical expression of allergic contact dermatitis (ACD) characterized by local DC-mediated T cell activation and recruitment of Ag-specific T cells to the sites of allergen challenge. We here made the novel observation that, in contrast to non-lesional skin of ACD patients, skin of (+) patch-tested individuals (effector phase of ACD) showed high expression of IL-15 in epidermal keratinocytes and in dermal DC-macrophage-T cell- clusters.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: J. Suwanpradid, P. Hoang, J. Kwock, L. Floyd, J. Smith, R. Kedl, A. Atwater, S. Rajagopal, D. Corcoran, A.S. MacLeod Tags: Adaptive and Auto-Immunity Source Type: research