013 NETs generate structured antimicrobial peptide-nucleosome immune complexes with inter-DNA spacings optimal for TLR9 activation

The molecular pathogenesis of psoriasis is characterized in part by breakdown of immune tolerance to self-DNA. Recent work demonstrates that the human antimicrobial peptide (AMP) LL37 overexpressed in psoriasis organizes naked DNA into periodic nanocrystals to potently hyperactivate Toll-like receptor 9 (TLR9) in plasmacytoid dendritic cells (pDCs). Interestingly, a subset of self-DNA in psoriatic lesions remain bound to histones as histone-DNA nucleosome core particles (NCPs) released from neutrophil extracellular traps (NETs).

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: E.Y. Lee, A. Leforestier, J. Di Domizio, T. Curk, L. Abbaspour, N. Berezhnoy, H. Fazli, L. Nordenskiold, J. Dobnikar, M. Gilliet, G.C. Wong Tags: Adaptive and Auto-Immunity Source Type: research