018 Langerhans cells suppress CD8 T cells in situ during acute graft-versus-host disease-like autoimmune mucocutaneous disease

Previous studies revealed that cutaneous manifestations of acute graft-versus-host disease (aGVHD) patients, in which donor immune cells react against host tissues after allogeneic hematopoietic stem cell transplant, are mediated by CD8 T cells. Cutaneous aGVHD is histologically characterized by reduced number of epidermal Langerhans cells (LCs). To investigate the roles of LCs, we analyzed a murine model using transgenic mice that express membrane-bound chicken ovalbumin under control of a keratin 14 promoter (K14-mOVA Tg mice), which develop aGVHD-like mucocutaneous disease after OVA-specific CD8 T cell (OT-I cell) transfer.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research