032 Il-1b is essential for anti-galectin3 antibody induced cutaneous vasculitis in systemic lupus erythematosus

Cutaneous vasculitis is one of the most common skin findings in systematic lupus erythematosus (SLE). However, the molecular mechanisms underlying this pathological process remain elusive. Our previous research suggested that anti-galectin-3 antibody was strongly related to the occurrence of cutaneous vasculitis in SLE patients. We here reported that anti-galectin3 antibody isolated from SLE patients induced cutaneous vasculitis in a dose-dependent manner by intradermal injection into mice. This antibody dysregulated the function of endothelial cells by inhibiting cell migration, capillary tubule formation and promoting inflammatory mediators production such as E-selectin, ICAM-1, IL-4 and IL-1b as well.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: Z. Shi, G. Tan, L. Wang Tags: Adaptive and Auto-Immunity Source Type: research