113 PRKAR2B is regulated by TOX and overexpressed in early stage mycosis fungoides

Mycosis fungoides (MF) and S ézary syndrome (SS) represent common and uncommon entities among primary cutaneous T cell lymphomas (CTCL). TOX is overexpressed in both of these CTCL entities and is correlated with disease severity and prognosis. TOX is a DNA-binding protein, which enables it to regulate the expression of multipl e downstream genes either directly or indirectly, thus supporting the malignant behavior of T cells in ways that are still unclear. Few validated markers exist which can be used to help discriminate early stage MF from benign inflammatory skin conditions.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: J. Liu, C. Chi, Y. Luo, Z. Liu, S.T. Hwang, Y. Liu Tags: Carcinogenesis and Cancer Genetics Source Type: research