129 Heterogeneity of CNV in primary acral subtype melanoma

Background: Both surgical treatment and targeting or immunotherapy of melanoma are based on the heterogeneity of melanoma. The lack of studies on primary acral subtype melanoma is mainly due to technical limitations of sample acquiring and sequencing. Objective: To study the heterogeneity of CNV in primary acral subtype melanoma at a variety of levels. Methods: Using LCM and MALBAC (Multiple Annealing and Looping Based Amplification Cycles) to portray the landscape of CNVs in 7 cases of primary acral subtype melanoma.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: H. Li, Y. Peng, X. Zhang, Y. Huang Tags: Carcinogenesis and Cancer Genetics Source Type: research