139 Transforming growth factor- β1 secreted by dermal fibroblasts induces an epithelial-to-mesenchymal transition in recessive dystrophic epidermolysis bullosa squamous cell carcinoma
Squamous cell carcinoma (SCC) develops in more than 80% of individuals with the skin blistering disorder recessive dystrophic epidermolysis bullosa (RDEB). In contrast with UV-induced SCC, RDEB SCC has a high proliferative and metastatic rate, with five-year survival near zero. RDEB dermal fibroblasts were found with higher expression of the myofibroblast markers α-smooth muscle actin (6/8 pairs), Fibronectin (7/8 pairs), and periostin (7/8 pairs) compared to matched donors. RDEB fibroblasts were also found to have higher expression of MCP-1 (3/4 pairs) and TGFβ1 (3/4 pairs), indicative of increased TGFβ1 secretion.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: W. Chen, K. Twaroski, M. Pickett-Leonard, J. Tolar Tags: Carcinogenesis and Cancer Genetics Source Type: research
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