149 Metformin as adjuvant in PDT in squamous cell carcinoma

Photodynamic therapy (PDT) is used for the treatment of several types of Non-Melanoma Skin Cancer (NMSC) although sometimes resistant cells responsible for the relapses may appear after treatment. Normal differentiated cells depend primarily on mitochondrial oxidative phosphorylation to generate energy, but cancer cells change this metabolism to an aerobic glycolysis (Warburg effect), which could influence in the response to antitumor drugs. Here, we have evaluated the expression of different proteins implicated in the energetic metabolism in the resistance to PDT of squamous cell carcinoma (SCC) in vitro and in vivo.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research