305 Study of the silencing of a combination of genes involved in cellular senescence in 3D skin bioengineered models

Cellular senescence is an irreversible state of cell cycle arrest that is induced during cellular aging. In the skin, senescence is associated with phenotypic changes in cutaneous structure and cells, lowered resistance to oxidative stress and DNA damage, decreased epidermal cell renewal, decreased synthesis of extracellular matrix protein and the appearance of markers of aging (senescence-associated beta-galactosidase, etc.). Many genes have been reported to be involved in the regulation of senescence: senescence genes, senescence suppressors, oncogenes, tumor suppressors, stemness genes, inflammation-related genes, genes involved in DNA damage repair and cytoskeletal remodeling as well as various transcription factors, ncRNAs and other genes related to epigenetic regulation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Barrier Function Source Type: research