370 Genetically corrected autologous keratinocyte epidermal grafts improve wound healing and patient reported outcomes in patients with recessive dystrophic epidermolysis bullosa
We report long term follow-up results of a single-center phase 1/2a study of 7 RDEB patients who underwent grafting of gene-corrected epidermal grafts from 2013-2017. Autologous keratinocytes were isolated from patient biopsies and transduced with GMP-grade retrovirus carrying full-length human COL7A1.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: S. Eichstadt, M. Barriga, C. Teng, N.T. Nguyen, E. Gorell, Z. Siprashvili, K. Loutit, Y. Dutt-Singkh, J. Nazaroff, M.P. Marinkovich, J. Tang Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
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