436 The role of the endosomal trafficking complex, the retromer, in regulating desmoglein-1 localization

The epidermis is a multi-layered and regenerating epithelial tissue that renews itself by proliferation of basal keratinocytes and the basal-to-suprabasal transition of differentiating cells. A desmosomal cadherin called desmoglein-1 (Dsg1) promotes basal cell delamination to the suprabasal layer via actin remodeling, a process which requires proper positioning of Dsg1 on the plasma membrane. The importance of Dsg1 positioning in epidermal function is reflected by the existence of mutations and autoantibodies that disrupt Dsg1 plasma membrane localization such as Severe dermatitis, multiple Allergies, and Metabolic wasting (SAM syndrome) and Pemphigus Foliaceus, respectively.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: M. Hegazy, O. Nekrasova, J. Koetsier, J.A. Broussard, L. Godsel, K. Green Tags: Growth Factors, Cell Adhesion, and Matrix Biology Source Type: research