464 A prospective trial for the clinical efficacy of topical washing with miconazole nitrate-containing soap to diaper candidiasis

Anogenital skin care for elderly remains an umbrella term concerning protective and non-interventional regimens, particularly for ordinary diaper users. Diapers provide an anxiety relief for excretion, but instead raise a prevalence of genital candidiasis. Our recent investigation has demonstrated the favorable preventive effect of topical washing with miconazole nitrate-containing soap to diaper candidiasis. We extended this work to the therapeutic benefit of the antifungal soap in substantial cases with genital candidiasis, who had at least 1 additional risk factor including diarrhea, cerebrovascular diseases, dementia, Parkinsonism, diabetes, pneumonia, chronic kidney diseases, heart failure, and malignancy.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research

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Publication date: Available online 25 May 2019Source: Social Science &MedicineAuthor(s): Ruth Bartlett, Tula BrannellyAbstractVulnerability is a problematic label routinely applied to people with dementia, yet their situated experiences of vulnerability have not been prioritised or documented. Drawing on empirical data collected using a novel methodology - walking interviews with 15 people with dementia living in Southern England, followed by a sit-down interview that included a nominated family member - this paper advances understanding of how vulnerability is experienced and dealt with by people with dementia when ou...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
This study attempts to highlight that females are still being negatively affected by existing gender stereotypes and prescribed gender identities despite relatively equal access and use of computer technology. This qualitative study aims to provide insights about the first-time user experience in a home environment of 16 middle school children in Turkey (8 males - 8 females), aged between 11 and 14 years, with a code learning game named “Code Combat”. The analysis is supported with complementary quantitative findings. The present study investigates the participants' conceptualizations and opinions toward coding...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
ConclusionAmong the presently studied Muslim population of Lucknow, a high prevalence of hypertension was found among both males and females. Also, WHR among males and WC among females were found to be better predictors of hypertension. Thus, for better prediction of risk of hypertension, sex and ethnicity specific adiposity indicator should be used in clinical practice.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Our weekly series of diabetes humor at DiabetesMine features a cartoon by Terry Keelan.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
ConclusionAS-IV protected H9c2 cells against hypoxia through down-regulating lncRNA GAS5. Besides, AS-IV might repress lncRNA GAS5 expression via activation of the PI3K/mTOR pathway.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
The study helps explain what the brain is doing with all the energy it consumes. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Brain Health subscribers-only Source Type: blogs
Publication date: June 2019Source: IJC Heart &Vasculature, Volume 23Author(s): David E. Winchester
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
People drinking this common beverage lost twice as much weight. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Weight Loss Source Type: blogs
Publication date: Available online 25 May 2019Source: American Heart JournalAuthor(s): Alexander C. Fanaroff, Amit N. Vora, Anita Y. Chen, Robin Mathews, Jacob A. Udell, Matthew T. Roe, Laine Thomas, Tracy Y. WangAbstractBackgroundLittle is known about the proportion of hospitals in the United States that offer clinical trial enrollment opportunities and how patient outcomes differ between hospitals that do and do not participate in clinical trials.MethodsIn the nationwide Chest Pain - MI registry, we described the proportion of hospitals that enrolled patients with acute myocardial infarction (MI) in clinical trials from ...
Source: American Heart Journal - Category: Cardiology Source Type: research
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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