476 S. aureus virulence factors enhance vaccinia virus infection in human keratinocytes

Orthopoxvirus infections are on the rise worldwide. In addition, a smallpox bioterrorism event would necessitate ring vaccination with vaccinia virus (VV). This would pose a significant threat to susceptible groups, such as patients with atopic dermatitis (AD). Subjects with AD, exposed to VV, can develop a serious complication called eczema vaccinatum (EV). As part of the Atopic Dermatitis Research Network, we have shown that a similar viral complication, called eczema herpeticum, is more common in AD subjects who are colonized with Staphylococcus aureus (S.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: M. Moran, M.G. Brewer, P. Schlievert, M. Cahill, T. Yoshida, B. Ward, S. Gill, L.A. Beck Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research