477 Identification of host cell factors involved HIV-1 trans-infection in dendritic cells

Dendritic cells (DC) are antigen presenting cells responsible for processing and presenting antigenic material to T-cells leading to the initiation of an adaptive immune response. DC are one of the first cells to encounter Human Immunodeficiency Virus-1 (HIV-1) transmitted via the sub-mucosal route. DC act as a ‘Trojan horse’ delivering the virus to an infectious synapse (IS), subsequently infecting target CD4+ T-cells. How HIV-1 is trafficked in DC to the IS is still unclear, therefore we conducted a siRNA screen in monocyte derived dendritic cells targeting 140 membrane trafficking genes with the aim of identifying host factors essential for IS formation in DC.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research