491 Cutaneous inflammation in the DIAMOND ™ mouse model of non-alcoholic fatty liver disease

The DIAMOND ™ model is an inbred isogenic C57BL/6J x 129S1/SvImJ mouse that develops features of the human metabolic syndrome including obesity, the spectrum of non-alcoholic fatty liver disease (NAFLD), and diabetes. Approximately 10% also develop a spontaneous dermatitis after being placed on Western Diet ( WDSW). The aim of this study was to investigate histologic features of the observed cutaneous inflammation and to screen for alterations in hepatic gene expression that may impact the skin. Lesional and adjacent normal skin were harvested from mice on WDSW and age-matched negative controls on a norm al chow/normal water diet (NCNW).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research