497 Staphylococcus aureus components increase Th2 response in cutaneous lymphoma

Mycosis fungoides and Sezary Syndrome are the most common types of cutaneous T-cell Lymphomas (CTCL) and are often characterized by a Th2-dominant phenotype. This Th2 microenvironment is advantageous for tumor cells but may cause higher susceptibility to infections. Indeed, it has been shown that Staphylococcus aureus (S. aureus) frequently colonizes the skin and nares of CTCL patients which can result in chronic and recurrent skin and systemic infections. Furthermore, patients colonized by S. aureus who were treated with antibiotics frequently show clinical improvement of their skin lesion, suggesting a possible functional role of S.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research