508 Phenotypic characterization of epidermal Langerhans cells precursor during embryonic development in human

Epidermal Langerhans cells (LCs) are skin-resident dendritic cells (DCs). Despite intense efforts, the exact phenotype of the epidermal LC precursors during human ontogeny has not been fully determined yet. The aim of this study was to further characterize the phenotype of LC precursors in human embryonic epidermis and to compare it with LCs in healthy adult skin by flow cytometry. After legal termination of pregnancy, the trunk skin at early embryonic [9-14 weeks estimated gestational age (EGA)], fetal (17-24 weeks EGA) and late prenatal (30 weeks EGA) stages were studied.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: Y. Xu, J. Zhang, L. Zhou, Q. Mi Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research