521 Ampicillin drives gut dysbiosis and progressive depigmentation in a mouse model of vitiligo.

As gut bacteria influence systemic immunity, we questioned whether vitiligo development is affected by microbial colonization of the developing gut. In arthritis-prone mice, neomycin but not ampicillin favors colonization of gut bacteria that activate Th17, enhancing antibody-mediated ankle thickening. Vitiligo, instead involves CD8 T cell-mediated depigmentation, therefor the same treatments might affect depigmentation differently. Pregnant vitiligo-prone FH mice received either ampicillin or neomycin-enriched drinking water, or normal water ad libitum.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: E. Dellacecca, C. Cosgrove, Z. Mukhatayev, S. Akhtar, V.H. Engelhard, A.W. Rademaker, K. Knight, I.C. Le Poole Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research